Reproducibility Category

Inpainting Missing Tissue in Multiplexed Immunofluorescence Imaging

Dec. 10, 2021—Shunxing Bao, Yucheng Tang, Ho Hin Lee, Riqiang Gao, Qi Yang, Xin Yu, Sophie Chiron, Lori A. Coburn, Keith T. Wilson, Joseph T. Roland, Bennett A. Landman, Yuankai Huo. “Inpainting Missing Tissue in Multiplexed Immunofluorescence Imaging” Medical Imaging 2022: Digital and Computational Pathology. International Society for Optics and Photonics, accepted Full text: [TBD] Abstract Multiplex immunofluorescence (MxIF) is...

Average shape and position of all bundles that are part of the TractEM protocol (association and projection pathways are shown only for the left hemisphere). The average was computed using segmentation from 4 raters and 4 datasets (BLSA) using a majority vote. This highlights the general agreement on the shape, but as seen in the lower right vignette the variability of each individual segmentation can be quite extreme.

TractEM: Evaluation of protocols for deterministic tractography white matter atlas

Dec. 3, 2021—Rheault, Francois, Roza G. Bayrak, Xuan Wang, Kurt G. Schilling, Jasmine M. Greer, Colin B. Hansen, Cailey Kerley et al. “TractEM: Evaluation of protocols for deterministic tractography white matter atlas.” Magnetic Resonance Imaging 85 (2022): 44-56. Full Text Abstract Purpose: One of the key challenges of the manual delineation of white matter pathways is human-rater’s subjectivity in labeling....

MASiVar: Multisite, Multiscanner, and Multisubject Acquisitions for Studying Variability in Diffusion Weighted Magnetic Resonance Imaging

Aug. 30, 2021—Leon Y. Cai, Qi Yang, Praitayini Kanakaraj, Vishwesh Nath, Allen T. Newton, Heidi A. Edmonson, Jeffrey Luci, Benjamin N. Conrad, Gavin R. Price, Colin B. Hansen, Cailey I. Kerley, Karthik Ramadass, Fang-Cheng Yeh, Hakmook Kang, Eleftherios Garyfallidis, Maxime Descoteaux, Francois Rheault, Kurt G. Schilling, and Bennett A. Landman. MASiVar: Multisite, Multiscanner, and Multisubject Acquisitions for...

Automated, open-source segmentation of the Hippocampus and amygdala with the open Vanderbilt archive of the temporal lobe

Aug. 28, 2021—Plassard, Andrew J., Shunxing Bao*, Maureen McHugo, Lori Beason-Held, Jennifer U. Blackford, Stephan Heckers, and Bennett A. Landman. “Automated, open-source segmentation of the Hippocampus and amygdala with the open Vanderbilt archive of the temporal lobe.” Magnetic Resonance Imaging 81 (2021): 17-23. Full text: https://www.sciencedirect.com/science/article/abs/pii/S0730725X21000692 Abstract Examining volumetric differences of the amygdala and anterior-posterior regions of the...

PreQual: An automated pipeline for integrated preprocessing and quality assurance of diffusion weighted MRI images

Jun. 23, 2021—Leon Y. Cai, Qi Yang, Colin B. Hansen, Vishwesh Nath, Karthik Ramadass, Graham W. Johnson, Benjamin N. Conrad, Brian D. Boyd, John P. Begnoche, Lori L. Beason-Held, Andrea T. Shafer, Susan M. Resnick, Warren D. Taylor, Gavin R. Price, Victoria L. Morgan, Baxter P. Rogers, Kurt G. Schilling, Bennett A. Landman. PreQual: An automated pipeline...

Generalizing deep whole-brain segmentation for post-contrast MRI with transfer learning

Dec. 26, 2020—Bermudez, C., Remedios, S. W., Ramadass, K., McHugo, M., Heckers, S., Huo, Y., & Landman, B. A. (2020). Generalizing deep whole-brain segmentation for post-contrast MRI with transfer learning. Journal of Medical Imaging, 7(6), 064004. Full Text: https://pubmed.ncbi.nlm.nih.gov/33381612/ Abstract Purpose: Generalizability is an important problem in deep neural networks, especially with variability of data acquisition in...

Different classes of methods have been used to infer tissue microstructure from single shell and multi shell DW-MRI data. The gap addressed herein is in data-driven machine learning models for multi-shell DW-MRI data.

Enabling Multi-shell b-Value Generalizability of Data-Driven Diffusion Models with Deep SHORE

Jan. 17, 2020—Nath V, Lyu I, Schilling KG, Parvathaneni P, Hansen CB, Huo Y, Janve VA, Gao Y, Stepniewska I, Anderson AW, Landman BA. Enabling Multi-shell b-Value Generalizability of Data-Driven Diffusion Models with Deep SHORE. In International Conference on Medical Image Computing and Computer-Assisted Intervention 2019 Oct 13 (pp. 573-581). Springer, Cham. Full text: https://arxiv.org/ftp/arxiv/papers/1907/1907.06319.pdf Abstract Intra-voxel...

The base regression neural network is depicted in the center which describes the parameters of the fullyconnected dense layers with respective activation functions. The plot at left: Depicts three inputs where the center input
comes from corresponding DW-MRI with histology. The other two are pairwise inputs from corresponding voxels of
scanner 1.5T and 3T. The plot at right: Depicts the loss function which uses the hypothesis that the outcome/prediction
should be same irrespective of the scanner gradient strength.

Harmonizing 1.5 T/3T diffusion weighted MRI through development of deep learning stabilized microarchitecture estimators

Jan. 17, 2020—Nath V, Remedios S, Parvathaneni P, Hansen CB, Bayrak RG, Bermudez C, Blaber JA, Schilling KG, Janve VA, Gao Y, Huo Y. Harmonizing 1.5 T/3T diffusion weighted MRI through development of deep learning stabilized microarchitecture estimators. In Medical Imaging 2019: Image Processing 2019 Mar 15 (Vol. 10949, p. 109490O). International Society for Optics and Photonics....

Violin plots of intrasession submissions across both the scanners per tract. (A) Dice similarity coefficients, (B) intraclass correlation coefficients. The top row depicts the median of the top five intrasession submissions. The tracts are in the following order (L/R): a) Uncinate, b) Fornix, c) Fminor & Fmajor, d) Cingulum, e) Corticospinal tract, f) Inferior longitudinal fasciculus, g) Superior longitudinal fasciculus, h) Inferior fronto‐occipital tract.

Tractography reproducibility challenge with empirical data (TRAceD): The 2017 ISMRM diffusion study group challenge

Jan. 17, 2020—Nath V, Schilling KG, Parvathaneni P, Huo Y, Blaber JA, Hainline AE, Barakovic M, Romascano D, Rafael‐Patino J, Frigo M, Girard G. Tractography reproducibility challenge with empirical data (traced): The 2017 ISMRM diffusion study group challenge. Journal of Magnetic Resonance Imaging. 2020 Jan;51(1):234-49. Full text: https://www.ncbi.nlm.nih.gov/pubmed/31179595 Abstract BACKGROUND: Fiber tracking with diffusion-weighted MRI has become an...

A) Middle axial slice of a human brain acquired using DW-MRI. B, C) CSD FOD's of the same subject on two different scanners showing inconsistency which cannot be validated without ground truth. D) Coronal slice of a Squirrel Monkey. E, F, G, H) Right: CSD FOD's at b-value of 3000 s/mm2 Left: Ground truth reconstruction using aggregated histological structural tensors depicting a loss in precision.

Deep learning reveals untapped information for local white-matter fiber reconstruction in diffusion-weighted MRI

Jan. 17, 2020—Nath V, Schilling KG, Parvathaneni P, Hansen CB, Hainline AE, Huo Y, Blaber JA, Lyu I, Janve V, Gao Y, Stepniewska I, Anderson AW, Landman BA. Deep learning reveals untapped information for local white-matter fiber reconstruction in diffusion-weighted MRI. Magnetic resonance imaging. 2019 Oct 1;62:220-7. Abstract PURPOSE: Diffusion-weighted magnetic resonance imaging (DW-MRI) is of critical importance...

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