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Extending the value of routine lung screening CT with quantitative body composition assessment

Nov. 28, 2022—Kaiwen Xu, Riqiang Gao, Yucheng Tang, Steve A. Deppen, Kim L. Sandler, Michael N. Kammer, Sanja L. Antic, Fabien Maldonado, Yuankai Huo, Mirza S. Khan, Bennett A. Landman Abstract Certain body composition phenotypes, like sarcopenia, are well established as predictive markers for post-surgery complications and overall survival of lung cancer patients. However, their association with...

Figure. Four consecutive modules of the atlas creation pipeline. (A) Preprocessing module: (A.1) original moving scan; (A.2) the overlap between the ambient removed scan and lung & body segmentation masks. (B) Affine registration module based on NiftyReg toolbox: (B.1) moving scan with intensity window (0, 1000); (B.2) axial view of reference scan; (B.3) reference scan with intensity window (0, 1000); (B.4) affine registered intensity windowed moving scan; (B.5) interpolation of the preprocessed moving scan with the affine registration transformation matrix. (C) Non-rigid registration module based on corrField (registration) and NiftyReg (interpolation): (C.1) affine registered moving scan overlapped with lung and body segmentation masks; (C.2) overlapped with non-NaN region mask; (C.3) reference scan with non-NaN region mask; (C.4) non-rigid deformed moving scan overlapped with deformed non-NaN region mask; (C.5) non-rigid deformed moving scan overlapped with deformed lung / body masks. (D) Atlas creation module: (D.1) average atlas of HU; (D.2) average atlas of Jacobian determinant map.

Development and Characterization of a Chest CT Atlas

Oct. 13, 2020—Kaiwen Xu, Riqiang Gao, Mirza S. Khan, Shunxing Bao, Yucheng Tang, Steve A. Deppen, Yuankai Huo, Kim L. Sandler, Pierre P. Massion, Mattias P. Heinrich, Bennett A. Landman. Development and characterization of a chest CT atlas. SPIE Medical Imaging, 2021. Full text: https://arxiv.org/abs/2012.03124 Abstract A major goal of lung cancer screening is to identify individuals...