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Medical-image Analysis and Statistical Interpretation Lab

Compressed Sensing of Multiple Intra-Voxel Orientations with Traditional DTI

Posted by on Monday, September 1, 2008 in Diffusion Tensor Imaging, Diffusion Weighted MRI, News.

A. Landman, J. Bogovic, and J. L. Prince. “Compressed Sensing of Multiple Intra-Voxel Orientations with Traditional DTI”, In Proceedings of the Workshop on Computational Diffusion MRI at the 11th International Conference on Medical Image Computing and Computer Assisted Intervention, New York, NY, September 2008.

Full Text:http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.701.4262&rep=rep1&type=pdf#page=183

Abstract

Diffusion tensor imaging (DTI) is widely used to characterize tissue microarchitecture and brain connectivity. However, traditional tensor techniques cannot represent multiple, independent intra-voxel orientations, so DTI suffers serious limitations in regions of crossing fibers. We present a new application of compressed sensing, Crossing Fiber Angular Resolution of Intra-voxel structure (CFARI), to resolve multiple tissue orientations. CFARI identifies a parsimonious tissue model on a strictly voxelwise basis using traditional DTI data. Reliable estimates of multiple intra-voxel orientations are demonstrated in simulations, and intra-voxel fiber orientations consistent with crossing fiber anatomy are revealed with typical in vivo DTI data.

 

CFARI identified consistent intra-voxel structure in the crossing fibers between the corpus callosum (CC, lower left, red) and internal capsule (IC, blue, lower right). Conventional tensor modeling does not preserve the connectivity of the corpus callosum to the lateral hemispheres
CFARI identified consistent intra-voxel structure in the crossing fibers between the corpus callosum (CC, lower left, red) and internal capsule (IC, blue, lower right). Conventional tensor modeling does not preserve the connectivity of the corpus callosum to the lateral hemispheres

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