‘DTI’

$(A) Significant associations with plasma C22:0 and subsequent FA. (A) Red–yellow indicates higher plasma C22:0 associated with lower FA in white matter regions, while cyan–blue indicates higher plasma C22:0 associated with higher FA. Regional statistics are overlaid onto an FA image from a single subject; results are not corrected for multiple comparisons. (B) ACR FA by mean centered Cer 22:0. (B) Association between FA in ACR and Cer 22:0. The residual FA of ACR was calculated by regressing standardized FA on baseline age, sex, interval between blood draw and DTI, diabetes, BMI, scanner, and ratio of white matter lesions to intracranial volume. This is shown plotted against mean centered Cer 22:0 with a linear fit overlaid. Abbreviations: ACR, anterior corona radiata; ALIC, anterior limb of internal capsule; BMI, body mass index; CG, cingulum of cingulate gyrus; DTI, diffusion tensor imaging; FA, fractional anisotropy; Scc, splenium of corpus callosum; SLF, superior longitudinal fasciculus; SS, sagittal stratum. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)$

Peripheral sphingolipids are associated with variation in white matter microstructure in older adults.

Jul. 31, 2016—Christopher E. Gonzalez, Vijay K. Venkatraman, Yang An, Bennett A. Landman, Christos Davatzikos, Veera Venkata Ratnam Bandaru, Norman J. Haughey, Luigi Ferruci, Michelle M. Mielke, Susan M. Resnick. “Peripheral sphingolipids are associated with variation in white matter microstructure in older adults.” Neurobiology of Aging. July 2016. Volume 43, Pages 156–163 Full Text: https://www.ncbi.nlm.nih.gov/pubmed/27255825 Abstract Sphingolipids...

Assessment of Bias in MRI Diffusion Tensor Imaging Parameters Using SIMEX

Mar. 2, 2013—Carolyn B. Lauzon, Ciprian Crainiceanu, Brian C. Caffo, Bennett A. Landman, “Assessment of Bias in MRI Diffusion Tensor Imaging Parameters Using SIMEX”, Magnetic Resonance in Medicine. 2013 Mar 1;69(3):891-902. PMC22611000 † Full Text: https://www.ncbi.nlm.nih.gov/pubmed/22611000 Abstract: Diffusion tensor imaging enables in vivo investigation of tissue cytoarchitecture through parameter contrasts sensitive to water diffusion barriers at the...

Correcting Power and p-Value Calculations for Bias in Diffusion Tensor Imaging.

Mar. 2, 2013—Carolyn B. Lauzon and Bennett A. Landman, “Correcting Power and p-Value Calculations for Bias in Diffusion Tensor Imaging.” Magnetic Resonance Imaging. 2013 Mar 2. pii: S0730-725X(13) PMC23465764 † Full Text: https://www.ncbi.nlm.nih.gov/pubmed/?term=Correcting+Power+and+p-Value+Calculations+for+Bias+in+Diffusion+Tensor+Imaging. Abstract: Diffusion tensor imaging (DTI) provides quantitative parametric maps sensitive to tissue microarchitecture (e.g., fractional anisotropy, FA). These maps are estimated through computational processes and...

Comparison of DTI and HARDI direction estimates. Mean unweighted scans (A, E) and DTI colormap images (B, F) are shown for two representative slices. Enlargements show estimated diffusion tensors (C, G) alongside CFARI directions (D, H) based on two repetitions of 30 directions at a b-value of 700 s/mm2

Resolution of Crossing Fibers with Constrained Compressed Sensing using Diffusion Tensor MRI

Feb. 1, 2012—Bennett A. Landman, John A Bogovic; Hanlin Wan; Fatma El Zahraa ElShahaby; Pierre-Louis Bazin, and Jerry L Prince. “Resolution of Crossing Fibers with Constrained Compressed Sensing using Diffusion Tensor MRI”, NeuroImage. 2012 Feb 1;59(3):2175-86. PMC22019877 Full text: https://www.ncbi.nlm.nih.gov/pubmed/22019877 Abstract Diffusion tensor imaging (DTI) is widely used to characterize tissue micro-architecture and brain connectivity. In regions...

Flow chart of steps to create SIMEX Estimated Bias and True Bias maps. Variables refer to terms defined explicitly by equations in the Theory section.

Assessment of bias for MRI diffusion tensor imaging using SIMEX

Sep. 30, 2011—Carolyn B. Lauzon, Andrew Asman, Ciprian Crainiceanu, Brian Caffo, Bennett A. Landman. “Assessment of Bias for MRI Diffusion Tensor Imaging Using SIMEX”, In International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), Toronto, Canada, September 2011 (30% acceptance rate) NIHMS ID 301343 Full text: https://www.ncbi.nlm.nih.gov/pubmed/21995019 Abstract Diffusion Tensor Imaging (DTI) is a Magnetic Resonance...

Intra-voxel orientations estimated with in vivo data show patterns consistent with anatomy, which can be clearly appreciated in the region of the corpus callosum (cc) and internal capsule (ic).

“Resolution of Crossing Fibers with Constrained Compressed Sensing using Traditional Diffusion Tensor MRI”

Feb. 12, 2010—A. Landman, H. Wan, J. Bogovic, P.-L. Bazin, and J. L. Prince. “Resolution of Crossing Fibers with Constrained Compressed Sensing using Traditional Diffusion Tensor MRI”, In Proceedings of the SPIE Medical Imaging Conference. San Diego, CA, February 2010 (Oral Presentation) PMC2854412 Full text Abstract Diffusion tensor imaging (DTI) is widely used to characterize tissue micro-architecture...

Simulations of free diffusion. Error between theoretical and simulated diffusion probability-density functions was minimized with 5–10 time-steps when the number of spins × the number of time-steps was held constant. Curves show mean error ± standard error for three diffusion times.

Complex Geometric Models of Diffusion and Relaxation in Healthy and Damaged White Matter

Jan. 31, 2010—. B. A. Landman, J. A.D. Farrell, S. A. Smith, D. Reich, P. Calabresi, and P. C.M. van Zijl, “Complex Geometric Models of Diffusion and Relaxation in Healthy and Damaged White Matter”, NMR in Biomed, Volume 23 Issue 2, Pages 152 – 162. (2010). PMC2838925 † Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838925/ Abstract Which aspects of tissue microstructure...

Interpolation of the genu of the Corpus Callosum (CC) and longitudinal fasciculus
(LF) near the lateral ventricle (V): region of interest (ROI) selected on an
orientation color coded anisotropy map (A,B). MD (C) and log-determinant (D) are
shown at the reconstructed resolution. Upsampled (4 × 4) and interpolated contrasts
are shown for linear (E-G), Log-Euclidean (H-J), and CLEAR (K-M) tensor interpolation.
While the linear interpolation has smooth FA and MD (E,F), it exhibits abrupt
changes in the determinant (G). The Log-Euclidean interpolation exhibits FA artifacts
in regions of high anisotropy and curvature (H). CLEAR avoids all these problems

Tensor Interpolation by Concise Local Estimation of Anisotropy and Rotation

Sep. 1, 2008—A. Landman, P-L. Bazin, and J. L. Prince. “Tensor Interpolation by Concise Local Estimation of Anisotropy and Rotation”, In Proceedings of the Workshop on Computational Diffusion MRI at the 11th International Conference on Medical Image Computing and Computer Assisted Intervention, New York, NY, September 2008. Full Text:http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.701.4262&rep=rep1&type=pdf#page=265 Abstract In diffusion tensor imaging, tensors represent the...

CFARI identified consistent intra-voxel structure in the crossing fibers between
the corpus callosum (CC, lower left, red) and internal capsule (IC, blue, lower right).
Conventional tensor modeling does not preserve the connectivity of the corpus callosum
to the lateral hemispheres

Compressed Sensing of Multiple Intra-Voxel Orientations with Traditional DTI

Sep. 1, 2008—A. Landman, J. Bogovic, and J. L. Prince. “Compressed Sensing of Multiple Intra-Voxel Orientations with Traditional DTI”, In Proceedings of the Workshop on Computational Diffusion MRI at the 11th International Conference on Medical Image Computing and Computer Assisted Intervention, New York, NY, September 2008. Full Text:http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.701.4262&rep=rep1&type=pdf#page=183 Abstract Diffusion tensor imaging (DTI) is widely used to...

Schematic of reliability estimation with experimental data (upper panel) and simulated data (lower panel).

Diffusion Tensor Imaging at Low SNR: Non-monotonic behaviors of tensor contrasts

Jul. 31, 2008—B. A. Landman, J. Farrell, H. Huang, J. Prince, and S. Mori. “Diffusion Tensor Imaging at Low SNR: Non-monotonic behaviors of tensor contrasts”, Magnetic Resonance Imaging. 26(6):790-800. July 2008 PMC2583784 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583784/ Abstract Diffusion tensor imaging (DTI) provides measurements of directional diffusivities and has been widely used to characterize changes in tissue micro-architecture in...

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