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Medical-image Analysis and Statistical Interpretation Lab

Comparison of Multi-Fiber Reproducibility of PAS-MRI and Q-ball With Empirical Multiple b-Value HARDI

Posted by on Friday, February 3, 2017 in News.

Vishwesh Nath, Kurt G. Schilling, Justin Blaber, Zhaohua Ding, Adam W. Anderson, Bennett A Landman. “Comparison of Multi-Fiber Reproducibility of PAS-MRI and Q-ball With Empirical Multiple b-Value HARDI ” In Proceedings of the SPIE Medical Imaging Conference. Orlando, Florida, February 2017. Oral presentation.

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Abstract

Crossing fibers are prevalent in human brains and a subject of intense interest for neuroscience. Here, we examine two leading approaches (PAS and Q-ball) in the context of a large-scale, single subject reproducibility study. A single healthy individual was scanned 11 times with 96 diffusion weighted directions and 10 reference volumes for each of five b-values (1000 – 3000 s/mm2) for a total of 5830 volumes. We examined the reproducibility of the number of fibers per voxel, volume fraction, and cross-fiber angles. These results can inform researchers when deciding between HARDI approaches or interpreting findings across studies.

 

Illustration of the differences in model fit for the gold standard datasets with: (A) PASMRI – 1000 s/mm2, (B) Q- ball – 1000 s/mm2, (C) PASMRI – 3000 s/mm2, and (D) Q-ball – 3000 s/mm2.
Illustration of the differences in model fit for the gold standard datasets with: (A) PASMRI – 1000 s/mm2, (B) Q- ball – 1000 s/mm2, (C) PASMRI – 3000 s/mm2, and (D) Q-ball – 3000 s/mm2.