Reproducibility Category

The base regression neural network is depicted in the center which describes the parameters of the fullyconnected dense layers with respective activation functions. The plot at left: Depicts three inputs where the center input
comes from corresponding DW-MRI with histology. The other two are pairwise inputs from corresponding voxels of
scanner 1.5T and 3T. The plot at right: Depicts the loss function which uses the hypothesis that the outcome/prediction
should be same irrespective of the scanner gradient strength.

Harmonizing 1.5 T/3T diffusion weighted MRI through development of deep learning stabilized microarchitecture estimators

Jan. 17, 2020—Nath V, Remedios S, Parvathaneni P, Hansen CB, Bayrak RG, Bermudez C, Blaber JA, Schilling KG, Janve VA, Gao Y, Huo Y. Harmonizing 1.5 T/3T diffusion weighted MRI through development of deep learning stabilized microarchitecture estimators. In Medical Imaging 2019: Image Processing 2019 Mar 15 (Vol. 10949, p. 109490O). International Society for Optics and Photonics....

Violin plots of intrasession submissions across both the scanners per tract. (A) Dice similarity coefficients, (B) intraclass correlation coefficients. The top row depicts the median of the top five intrasession submissions. The tracts are in the following order (L/R): a) Uncinate, b) Fornix, c) Fminor & Fmajor, d) Cingulum, e) Corticospinal tract, f) Inferior longitudinal fasciculus, g) Superior longitudinal fasciculus, h) Inferior fronto‐occipital tract.

Tractography reproducibility challenge with empirical data (TRAceD): The 2017 ISMRM diffusion study group challenge

Jan. 17, 2020—Nath V, Schilling KG, Parvathaneni P, Huo Y, Blaber JA, Hainline AE, Barakovic M, Romascano D, Rafael‐Patino J, Frigo M, Girard G. Tractography reproducibility challenge with empirical data (traced): The 2017 ISMRM diffusion study group challenge. Journal of Magnetic Resonance Imaging. 2020 Jan;51(1):234-49. Full text: https://www.ncbi.nlm.nih.gov/pubmed/31179595 Abstract BACKGROUND: Fiber tracking with diffusion-weighted MRI has become an...

A) Middle axial slice of a human brain acquired using DW-MRI. B, C) CSD FOD's of the same subject on two different scanners showing inconsistency which cannot be validated without ground truth. D) Coronal slice of a Squirrel Monkey. E, F, G, H) Right: CSD FOD's at b-value of 3000 s/mm2 Left: Ground truth reconstruction using aggregated histological structural tensors depicting a loss in precision.

Deep learning reveals untapped information for local white-matter fiber reconstruction in diffusion-weighted MRI

Jan. 17, 2020—Nath V, Schilling KG, Parvathaneni P, Hansen CB, Hainline AE, Huo Y, Blaber JA, Lyu I, Janve V, Gao Y, Stepniewska I, Anderson AW, Landman BA. Deep learning reveals untapped information for local white-matter fiber reconstruction in diffusion-weighted MRI. Magnetic resonance imaging. 2019 Oct 1;62:220-7. Abstract PURPOSE: Diffusion-weighted magnetic resonance imaging (DW-MRI) is of critical importance...

Fig. 1. Past challenges in fiber tractography. Detailed description of data, ground truth, and evaluation are described in the text. (A) FiberCup Phantom pathways with 16 ground truth bundles [21]. (B) Eight example CST reconstructions from the DTI Challenge [23]. (C) Synthetic fiber fields from the HARDI Reconstruction Challenge [26]. (D) Phantomas [27] dataset for Tractometer evaluation [28]. (E) Creation of simulated in vivo human dataset for the ISMRM Tractography Challenge [29]. (F) Example submissions from the TraCED Reproducibility Challenge for two white matter pathways. (G) 3D-VoTEM ground truths defined on the macaque, squirrel monkey, and phantom (from left to right).

Challenges in diffusion MRI tractography – Lessons learned from international benchmark competitions

Dec. 15, 2018—Kurt G Schilling, Alessandro Daducci, Klaus Maier-Hein, Cyril Poupon, Jean-Christophe Houde, Vishwesh Nath, Adam W Anderson, Bennett A Landman, Maxime Descoteaux. “Challenges in Diffusion MRI Tractography – Lessons Learned from International Benchmark Competitions”. Magnetic Resonance Imaging. 2018. doi: 10.1016/j.mri.2018.11.014 Full text: NIHMSID https://www.sciencedirect.com/science/article/pii/S0730725X18305162#f0005 Abstract Diffusion MRI (dMRI) fiber tractography has become a pillar of the neuroimaging...

Technology Enablers for Big Data, Multi-Stage Analysis in Medical Image Processing

Oct. 26, 2018—Shunxing Bao, Prasanna Parvathaneni, Yuankai Huo, Yogesh Barve, Andrew J. Plassard, Yuang Yao, Hongyang Sun, Ilwoo Lyu, David H. Zald, Bennett A. Landman and Aniruddha Gokhale. “Technology Enablers for Big Data, Multi-Stage Analysis in Medical Image Processing.” Big Data (Big Data), 2018 IEEE International Conference. (accepted) (acceptance rate 18.9%) Full text: TBD Abstract Big data medical image processing...

Harmonization of white and gray matter features in diffusion microarchitecture for cross sectional studies

Jun. 25, 2018—Prasanna Parvathaneni, Shunxing Bao , Allison Hainline , Yuankai Huo , Kurt G. Schilling , Hakmook Kang , Owen Williams , Neil D. Woodward , Susan M. Resnick , David H. Zald , Ilwoo Lyu , Bennett A. Landman “Harmonization of white and gray matter features in diffusion microarchitecture for cross sectional studies.” In International Conference on Clinical and Medical Image Analysis 2018 (ICCMIA’18) – Accepted Abstract Understanding of the specific processes...

Empirical Reproducibility, Sensitivity, and Optimization of Acquisition Protocol for Neurite Orientation Dispersion and Density Imaging using AMICO

Apr. 6, 2018—Prasanna Parvathaneni, Vishwesh Nath, Justin A. Blaber, Kurt G Schilling, Allison E. Hainline, Adam W Anderson, and Bennett A. Landman “Empirical Reproducibility, Sensitivity, and Optimization of Acquisition Protocol for Neurite Orientation Dispersion and Density Imaging using AMICO”. Magnetic Resonance Imaging. Mar 2018. Abstract Neurite Orientation Dispersion and Density Imaging (NODDI) is a relatively new model for diffusion weighted...

$QBI glyphs in crossing fiber (left) and single fiber (right) regions, for various b-values, number of gradient directions, and maximum SH order fit. Glyphs are shown min-max normalized and are displayed on top of fractional anisotropy maps.$

Empirical consideration of the effects of acquisition parameters and analysis model on clinically feasible q-ball imaging

May. 5, 2017—Kurt G. Schilling, Vishwesh Nath, Justin Blaber Prasanna Parvathaneni, Adam W. Anderson, Bennett A. Landman. “Empirical consideration of the effects of acquisition parameters and analysis model on clinically feasible q-ball imaging” Magnetic Resonance Imaging. Submitted November 2016. (In Press). Full Text: https://www.ncbi.nlm.nih.gov/pubmed/28438712 Abstract Q-ball imaging (QBI) is a popular high angular resolution diffusion imaging (HARDI) technique used...

Improving Cerebellar Segmentation with Statistical Fusion

Feb. 27, 2016—Andrew J. Plassard, Zhen Yang, Swati D. Rane, Jerry L. Prince, Daniel O. Claassen, Bennett A. Landman. “Improving Cerebellar Segmentation with Statistical Fusion. In Proceedings of the SPIE Medical Imaging Conference. San Diego, California, February 2016. Full Text: https://www.ncbi.nlm.nih.gov/pubmed/?term=Improving+Cerebellar+Segmentation+with+Statistical+Fusion Abstract The cerebellum is a somatotopically organized central component of the central nervous system well known...

Short Term Reproducibility of a High Contrast 3-D Isotropic Optic Nerve Imaging Sequence in Healthy Controls

Feb. 1, 2016—Robert L. Harrigan, Alex K. Smith, Louise A. Mawn, Seth A. Smith, Bennett A. Landman. “Short Term Reproducibility of a High Contrast 3-D Isotropic Optic Nerve Imaging Sequence in Healthy Controls.” In Proceedings of the SPIE Medical Imaging Conference. San Diego, California, February 2016. Oral presentation. Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862660/?report=classic Abstract The optic nerve (ON) plays a...

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